Correction: Moustafa, I.M.; et al. Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome? Viruses 2015, 7, 5962–5986
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چکیده
Supplementary Materials: The following are available online at http://www.mdpi.com/1999-4915/7/11/2919, Figure S1: DLS analysis of PV 3CD protein, Figure S2: PCA analysis reveal major motions of 3CD, Figure S3: MD simulations reveal multiple interfaces in WT and mutant 3CD, Figure S4: Mutations of 3CD in the crystal structure, Figure S5: Analysis of the 50 ns MD simulations of mutant PV 3CD, and Video S1: Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?; DOI: 10.5281/zenodo.34538.
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Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?
The genomes of RNA viruses are relatively small. To overcome the small-size limitation, RNA viruses assign distinct functions to the processed viral proteins and their precursors. This is exemplified by poliovirus 3CD protein. 3C protein is a protease and RNA-binding protein. 3D protein is an RNA-dependent RNA polymerase (RdRp). 3CD exhibits unique protease and RNA-binding activities relative t...
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